The research group Applied Systems Biology is concerned with the mathematical modeling and computer simulation of infection processes caused by human-pathogenic fungi.
The spatio-temporal data basis for these models is acquired by automatizing the data analysis of microscopy images on infection processes for high-throughput scanning. Our aim is to unravel secrets of the dynamical, functional and morphological aspects of the host-pathogen interaction using approaches of image-based systems biology.
Image-based Systems Biology seeks to take full advantage of the information contained in images and includes:
- Automated image analysis data for high-content and high-throughput screening.
- Quantitative characterization of biological processes by appropriate characteristic measures.
- Construction of image-derived spatio-temporal models and predictive computer simulations.
Latest Publications
News & Announcements
ASB Christmas dinner 2024
This year, we celebrated Christmas with a joyful evening of bowling, laughter, and festive cheer. Strikes and spares were accompanied by warm conversations, creating a wonderful mix of team spirit and holiday mood. It was a delightful way to wrap up the year and share some Christmas magic together!
Medac research award 2024
Source : https://www.leibniz-hki.de/en/press-release/medac-research-award-2024-awarded-for-pioneering-research-work-at-the-leibniz-hki.html The Leibniz-HKI has awarded the medac Research Award 2024, recognizing outstanding interdisciplinary publications on infectious diseases and anti-infective development. Among the four winning studies is a groundbreaking gut-on-chip model, published in Biomaterials, showing how caspofungin affects Candida albicans. This innovative research advances infection studies without animal testing. The award celebrates the successful […]
Welcoming Karoline and Jana to our research team!
We are thrilled to welcome two new PhD students, Karoline and Jana, to the Applied Systems Biology group! Having successfully completed their master’s theses with us, they are now embarking on exciting doctoral journeys. Karoline brings her expertise in modeling organ-on-chip systems, while Jana contributes her skills in machine-learning based surrogate modeling, both backed by […]
Collaborations, Funding & Teaching
Image-based systems biology represents a generic link between experiment and theory in interdisciplinary studies and offers an enormous range of opportunities for cooperation, since microscopic and spectroscopic data are routinely collected in nowadays experiments. This explains why the research group Applied Systems Biology is an active collaboration partner in the BMBF-funded Center for Sepsis Control and Care at the Jena University Hospital as well as in two DFG-funded collaborative research centers in Jena: FungiNet 124 – “Pathogenic fungi and their human host – networks of interaction” (Project B4) and PolyTarget 1278 – “Polymer-based nanoparticle libraries for targeted anti-inflammatory strategies” (Project Z01). In the newly established Excellence Cluster – “Balance of the Microverse” at the Friedrich Schiller University Jena, Prof. Figge is coordinator of the research area on “Data Synopsis” as well as a member in the interdisciplinary management board of the “Microverse Imaging Center”. Furthermore, Prof. Figge is the speaker of the Leibniz-funded ScienceCampus InfectoOptics, which is a collaborative initiative where researchers from the life sciences and optics/photonics closely work together with the aim of investigating and combating infectious diseases by means of novel optical technologies. In the Research Campus InfectoGnostics, methods for application in the diagnosis of infections are being further developed; for example, in the ADA project, where a platform for screening for Staphylococcus aureus / MRSA in human and veterinary medicine is being developed.
Every year, the research group Applied Systems Biology is involved in the organization of an international symposium with two alternating topics: Image-based Systems Biology (IbSB) in the even years and Systems Biology of Microbial Infection (SBMI) in the uneven years. Each of these events attracts an international audience to the HKI of more than 70 participants.
Last but not least, the research concept is further supported by the lectures on Image-based Systems Biology and Systems Biology of Immunology to educate bachelor and master students in this modern research approach and to teach the basics of analytical and quantitative methods for modeling dynamic systems.
Taken together, the research group Applied Systems Biology is a link between the two profile lines LIGHT and LIFE of the Friedrich Schiller University Jena. This is also reflected by Prof. Figge’s membership in the faculties of the Jena School for Microbial Communication, the International Leibniz Research School for Microbial and Biomolecular Interactions, as well as the Jena Center for Soft Matter and the Michael Stifel Center Jena.
