2026-07-28

Assessing the proinflammatory potential of sterile fecal microbiome filtrate from ulcerative colitis patients using an intestine-on-chip platform and automated image analysis

Schaal T*, Akbarimoghaddam P*, Wegner VD, Steube A, Gardey E, Feile A, Hassan MIA, Cseresnyés Z, Stallmach A, Mosig AS, Figge MT#, Stallhofer J#

Gut Microbes 18(1)

2026-07-24

Functional analysis of Candida albicans protein kinases identifies Crk1 as a modulator of epithelial cell damage

Anna Möslinger , Dr. Allon Weiner , Sascha Schäuble , Dr. Bernardo Ramírez-Zavala , Nadja Jablonowski , Zoltán Cseresnyés , Tim Bastian Schille , Prof. Marc Thilo Figge , Prof. Gianni Panagiotou , Dr. Joachim Morschhäuser , Dr. Lydia Kasper , Mark Gresnigt , Ms. Stefanie Allert , Prof. Bernhard Hube (corr-auth)

mBio

2026-07-24

Reconstructing host-pathogen interactions: analysis of the intercellular network of macrophages and other immune cells within an Aspergillosis-on-chip model.

Simranpreet Kaur*, Anna Katharina Renner*, Pauline Porschitz*, Franziska Schmidt*, Svenja Grau, Hannah Afolayan, Stanislaw Schmidt, Thomas Lehrnbecher-Lanzeni, Hubertus Haas, Axel A. Brakhage, Marc Thilo Figge, Marie von Lilienfeld-Toal, Zoltan Cseresnyés*, Susann Hartung*, Susanne Jahreis*

microLife

2026-05-15

Human Colitis-on-Chip Model Reveals Dual Roles of Butyrate in Epithelial and Macrophage Defense Against Candida albicans Tissue Invasion

Manuel Allwang*, Maximilian Wipplinger*, Parastoo Akbarimoghaddam*, Raquel Alonso-Roman, Zoltan Cseresnyes, Axel Dietschmann, Valentin Wegner, Adrian Feile, Yann Bachelot, Maria Warschinke, Mohamed I Abdelwahab Hassan, Sonnhild Mittag, Otmar Huber, Bernhard Hube, Mark S. Gresnigt, Marc Thilo Figge, Alexander S. Mosig#

small

2026-05-04

Mesenchymal stroma cell-derived stem cell factor mediates cross-species compatibility of the hematopoietic stem cell niche

Julia Froebel*, Susann Rahmig*, Jonas Metz, Iwo Kucinski, Carl-Magnus Svensson, Susanne Reinhardt, Juliane Salbach-Hirsch, Emilie Coppin, Nicole Mende, Nina Henning, Guelce Percin, Friederike Weschenfelder, Alexandra Koehler, Alexander Platz, Berthold Goettgens, Martina Rauner, Marc Thilo Figge, Thomas Hoefer, Andreas Dahl, Claudia Waskow#

bioRxiv

2026-04-16

Expression of Human CEACAM Receptors Promotes Inflammation and Organ Damage During Systemic Candida albicans Infection in Mice

Esther Klaile#, Mario Marco Müller, Johannes Sonnberger, Anne-Katrin Bothe, Saskia Brehme, Juliet Ehrenpfordt, Tilman Eike Klassert, Sabina Kuhn, Kristina Dietert, Olivia Kershaw, Jan-Philipp Praetorius, Marc Thilo Figge, Torsten Bauer, Andreas Gebhardt, Gita Mall, Ilse Denise Jacobsen, Hortense Slevogt#

Cells

2026-03-26

Overcoming Protein A-driven Nonspecific Antibody Staining of S. aureus in Immunofluorescence Microscopy

Lena Gauthier, Bettina Löffler, Marc Thilo Figge, Christina Ehrhardt, Christian Eggeling#

bioRxiv

2026-03-04

Environmental cues shape extracellular vesicles biogenesis and function in Streptococcus pneumoniae

Miriana Battista, Yann Bachelot, Teresa Franke, Christoph Saffer, Lioba Zimmermann, Laura Teuber, Marc Thilo Figge & Cláudia Vilhena#

BMC Microbiology

2026-02-07

From Observation to Mechanistic Insight: Image-based Systems Biology of Human Pathogenic Fungi

Anastasia Solomatina, Mounir Zerdani, Karoline Schied, Marc Thilo Figge#

Current Clinical Microbiology Reports

2025-12-30

Generation of an Induced Pluripotent Stem Cell-Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Lena Gauthier*, Hristina Koceva*, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling#, Alexander Sandy Mosig#

Advanced Healthcare Materials

2025-11-16

Mechanistic Insights into the Role of Extracellular Vesicles at the Bacterial−Host Interface

Miriana Battista, Christoph Saffer, Marc Thilo Figge and Cláudia Vilhena*

ACS Infectious Diseases

2025-11-10

Evaluating the antiviral efficacy of encapsulated PKC inhibitor BIM-I against influenza A virus infection

Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffman

Advanced Healthcare Materials

2025-09-25

Multiplexed, rapid phenotypic antibiotic susceptibility testing based on angle-resolved light scattering imaging of microfluidic droplets.

Martina Graf, Arjun Sarkar, Carl-Magnus Svensson, Anne-Sophie Munser, Sven Schröder, Elke Müller, Sundar Hengoju, Marc Thilo Figge, Miriam A Rosenbaum#

Journal of Advanced Research

2025-09-15

Selective activation of dynamics in kinetically frozen supramolecular polymer bottlebrush assemblies

Hans F. Ulrich, Tobias Klein, Ziliang Zhao, Zoltán Cseresnyés, Pablo Carravilla, Ruman Gerst, Alina Kasberg, Frederic P. Scharfenberg, Marc Thilo Figge, Christian Eggeling, Johannes C. Brendel

Small

2025-07-22

Complex-mediated evasion: modeling defense against antimicrobial peptides with application to human-pathogenic fungus Candida albicans

Yann Bachelot, Anastasia Solomatina & Marc Thilo Figge#

npj Systems Biology and Applications

2025-03-13

Image-based quantification of Candida albicans filamentation and hyphal length using the open-source visual programming language JIPipe

Jan-Philipp Praetorius*, Sophia U. J. Hitzler*, Mark S. Gresnigt#, Marc Thilo Figge#

FEMS Yeast Research

2025-03-06

Convergent evolution of a fungal effector enabling phagosome membrane penetration

Lei-Jie Jia, Freddy Alexander Bernal, Jeany Söhnlein, Johannes Sonnberger, Isabel Heineking, Muhammad Rafiq, Zoltán Cseresnyés, Franziska Kage, Franziska Schmidt, Rasha Zaher, Peter Hortschansky, Shivam Chaudhary, Xuemin Gong, Jan Schirawski, Marc Thilo Figge, Bernhard Hube, Axel A. Brakhage

bioRxiv

2025-03-05

Deciphering respiratory viral infections by harnessing organ-on-chip technology to explore the gut–lung axis

Hristina Koceva, Mona Amiratashani, Parastoo Akbarimoghaddam, Bianca Hoffmann, Gaukhar Zhurgenbayeva, Mark S. Gresnigt, Vanessa Rossetto Marcelino, Christian Eggeling, Marc Thilo Figge, Maria-João Amorim and Alexander S. Mosig

Open Biology

2025-03-01

Intuitive workflows for automated image analysis - JIPipe as an open-source tool for FAIR image analysis.

Ruman Gerst, Zoltán Cseresnyés, Figge#

Microscopy and Analysis

2025-02-19

Intuitive Abläufe für die automatisierte Bildanalyse. JIPipe als quelloffene Softwarelösung für FAIRe Bildanalyse

Gerst R, Cseresnyés Z, Figge MT#

Wiley Analytical Science

2025-02-01

Rapid detection of microbial antibiotic susceptibility via deep learning supported analysis of angle-resolved scattered-light images of picoliter droplet cultivations

Sarkar A*, Graf M*, Svensson CM, Munser A-S, Schröder S, Hengoju S, Rosenbaum M, Figge MT

Sensors and Actuators B: Chemical

2025-02-01

Targeting protein kinase C-α prolongs survival and restores liver function in sepsis: Evidence from preclinical models

Ling Xiong, Dustin Beyer, Na Liu, Tina Lehmann, Sophie Neugebauer, Sascha Schaeuble, Oliver Sommerfeld, Philipp Ernst, Carl-Magnus Svensson, Sandor Nietzsche, Sebastian Scholl, Tony Bruns, Nikolaus Gaßler, Markus H Gräler, Marc Thilo Figge, Gianni Panagiotou, Michael Bauer, Adrian T Press

Pharmacological Research

2025-01-30

Oncogenic FLT3 internal tandem duplications (ITD) and CD45/PTPRC control osteoclast functions and bone microarchitecture

Carolin Lossius-Cott, Akua Annoh, Martin Bens, Sandor Nietzsche, Bianca Hoffmann, Marc Thilo Figge, Martina Rauner, Lorenz C Hofbauer, Jörg P Müller

2024-12-05

The proteomic response of Aspergillus fumigatus to amphotericin B (AmB) reveals the involvement of the RTA-like protein RtaA in AmB resistance

Ammar Abou-Kandil, Sophie Tröger-Görler, Annica Pschibul, Thomas Krüger, Maira Rosin, Franziska Schmidt, Parastoo Akbarimoghaddam, Arjun Sarkar, Zoltán Cseresnyés, Yana Shadkchan, Thorsten Heinekamp, Markus H Gräler, Amelia E Barber, Grit Walther, Marc Thilo Figge, Axel A Brakhage, Nir Osherov, Olaf Kniemeyer

MicroLife

2024-11-10

Spatiotemporal modeling quantifies cellular contributions to uptake of Aspergillus fumigatus in the human lung

Saffer C, Timme S, Ortiz SC, Bertuzzi M, Figge MT

Communications Biology

2024-11-06

Tracking the uptake of labelled host-derived extracellular vesicles by the human fungal pathogen Aspergillus fumigatus

Visser C, Rivieccio F, Krüger T, Schmidt F, Cseresnyés Z, Rohde M, Figge MT, Kniemeyer O,Blango MG*, Brakhage AA*

microLife

2024-09-13

Aspergillus fumigatus-derived gliotoxin impacts innate immune cell activation through modulating lipid mediator production in macrophages

Günther K, Nischang V, Cseresnyés Z, Krüger T, Sheta D, Abboud Z, Heinekamp T, Werner M, Kniemeyer O, Beilhack A, Figge MT, Brakhage AA, Werz O#, Jordan PM#

Immunology

2024-09-12

Engineering Adhesion of the Probiotic Strain Escherichia coli Nissle to the Fungal Pathogen Candida albicans

Chamas A#, Svensson CM, Maneira C, Sporniak M, Figge MT, Lackner G

ACS Synth Biol

2024-08-30

Metamizole outperforms meloxicam in sepsis: insights on analgesics, survival and immunomodulation in the peritoneal contamination and infection sepsis model

Liu N, Sonawane M, Sommerfeld O, Svensson CM, Figge MT, Bauer Reinhard , Bischoff SJ,Bauer M, Osuchowski MF, Press AT

Frontiers in Immunology

2024-08-07

NFDI4BIOIMAGE – National research data infrastructure for microscopy and bioimage analysis

Moore J#, Kunis S, Grüning B, Blank-Burian M, Mallm JP, Stöter T, Zuschratter W, Figge MT, Kreshuk A, Tischer C, Haase R, Zobel T, Bauer P, Svensson CM, Gerst R, Hanne J, Schmidt C, Becker MM, Bocklitz T, Bumberger J, Chalopin C, Chen J, Czodrowski P, Dickscheid T, Fortmann- Grote C, Huisken J, Lohmann J, Schauss A, Baumann M, Beretta C, Burel JM, Heuveline C, Kuner R, Kuner T, Landwehr M, Leibfried A, Nitschke R, Mittal D, von Suchodoletz D, Valencia- Schneider M, Zentis P, Brilhaus D, Hartley M, Hülsmann B, Dunker S, Keppler A, Mathur A, Meesters C, Möbius W, Nahnsen S, Pfander C, Rehwald S, Serrano-Solano B, Vilardell Scholten L, Vogl R, Becks L, Ferrando-May E*#, Weidtkamp-Peters S*#

Zenodo

2024-07-23

Unique target binding by the C-terminal Region of FHR1 provides a new perception of aHUS Pathology

Luce Perie, Selina Stippa, Christoph Saffer, Andrea Hartmann , Mathias Mörgelin, Svante L. H. Zipfel, Marc Thilo Figge, Thorsten Wiech, Christine Skerka, and Peter F. Zipfel

Front. Hematol.

2024-06-10

Competitive inhibition and mutualistic growth in Co infections: deciphering Staphylococcus aureus – Acinetobacter baumannii interaction dynamics

Timme S*, Wendler S*, Klassert TE, Saraiva JP, Nunes da Rocha U, Wittchen M, Schramm S, Ehricht R, Monecke S, Edel B, Rödel J, Löffler B, Soledad Ramirez M, Slevogt H, Figge MT*#, Tuchscherr L*#

ISME Commun

2024-05-28

Impact of functional electrical stimulation on nerve-damaged muscles by quantifying fat infiltration using deep learning

Walluks, K.*, Praetorius*, JP., Arnold, D. #, Figge, M. T.#

Scientific Reports

2024-05-23

Selective Uptake Into Inflamed Human Intestinal Tissue and Immune Cell Targeting by Wormlike Polymer Micelles

Elena Gardey, Zoltan Cseresnyes, Fabian H. Sobotta, Juliane Eberhardt, Drilon Haziri, Philip C. Grunert, Maren T. Kuchenbrod, Franka V. Gruschwitz, Stephanie Hoeppener, Michael Schumann, Nikolaus Gaßler, Marc T. Figge, Andreas Stallmach, Johannes C. Brendel

Small

2024-05-08

Long-term stimulation by implanted pacemaker enables non-atrophic treatment of bilateral vocal fold paresis in a human-like animal model

Walluks K*, Hoffmann B*, Svensson CM, Förster G, Müller AH, Jarvis J, Perkins J, Figge MT#, Arnold D#; *contributed equally and #contributed equally

Scientific Reports

2024-04-22

Invasive aspergillosis-on-chip: A quantitative treatment study of human Aspergillus fumigatus infection

Hoang TNM*, Cseresnyés Z*, Hartung S*, Blickensdorf M, Saffer C, Rennert K, Mosig AS, von Lilienfeld-Toal M, Figge MT

Biomaterials

2024-03-25

Organ-on-chip models for infectious disease research

Alonso-Roman R, Mosig AS, Figge MT, Papenfort K, Eggeling C, Schacher FH, Hube B, Gresnigt MS

Nature Microbiology

2024-03-25

Organ-on-chip models for infectious disease research

Raquel Alonso-Roman, Alexander S. Mosig, Marc Thilo Figge, Kai Papenfort, Christian Eggeling, Felix H. Schacher, Bernhard Hube#, Mark S. Gresnigt

Nature Microbiology

2024-03-09

Deep learning-based characterization of neutrophil activation phenotypes in ex vivo human Candida blood infections

Sarkar A, Praetorius JP, Figge MT#

Computational and Structural Biotechnology Journal

2024-03-06

Modeling of intravenous caspofungin administration using an intestine-on-chip reveals altered Candida albicans microcolonies and pathogenicity

Kaden T*, Alonso-Roman R*, Akbarimoghaddam P*, Mosig AS, Graf K, Raasch M, Hoffmann B, Figge MT#, Hube B#, Gresnigt MS#

Biomaterials

2024-02-21

The spatial organization of sphingofungin biosynthesis in Aspergillus fumigatus and its cross-interaction with sphingolipid metabolism

Jojić K*, Gherlone F*, Cseresnyés Z, Bissell AU, Hoefgen S, Hoffmann S, Huang Y, Janevska S, Figge MT, Valiante V

Molecular and Cellular Biology

2024-02-20

The global RNA–RNA interactome of Klebsiella pneumoniae unveils a small RNA regulator of cell division

Ruhland E, Siemers M*, Gerst R*, Späth F, Vogt LN, Figge MT, Papenfort K, Fröhlich KS#

Proc Natl Acad Sci

2024-02-13

Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis

Valentine M*, Rudolph P*, Dietschmann A, Tsavou A, Mogavero S, Lee S, Priest EL, Zhurgenbayeva G, Jablonowski N, Timme S, Eggeling C, Allert S, Dolk E, Naglik JR, Figge MT, Gresnigt MS*#, Hube B*#

mBio

2024-01-08

IMFSegNet: Cost-effective and objective quantification of intramuscular fat in histological sections by deep learning

Praetorius JP, Walluks K, Svensson CM, Arnold D, Figge MT#

Comput Struct Biotechnol J

2023-12-18

Selective Uptake Into Inflamed Human Intestinal Tissue and Immune Cell Targeting by Wormlike Polymer Micelles

Gardey E, Cseresnyés Z, Sobotta FH, Eberhardt J, Haziri D, Grunert PC, Kuchenbrod MT, Gruschwitz FV, Hoeppener S, Schumann M, Gaßler N, Figge MT, Stallmach A#, Brendel JC#

Small

2023-11-23

pyPESTO: a modular and scalable tool for parameter estimation for dynamic models

Schälte Y*, Fröhlich F*, Jost PJ*, Vanhoefer J*, Pathirana D, Stapor P, Lakrisenko P, Wang D, Raimúndez E, Merkt S, Schmiester L, Städter P, Grein S, Dudkin E, Doresic D, Weindl D, Hasenauer J#

Bioinformatics

2023-11-11

Quantitative analysis of peroxisome tracks using a Hidden Markov Model

Svensson CM*, Reglinski K*, Schliebs W, Erdmann R, Eggeling C#, Figge MT#

Sci Rep

2023-10-18

Contribution of Radixin and Ezrin to the maintenance of hepatocytes’ excretory function in health and disease

Dellbrügge F, Jesse LD, Medyukhina A, Liu N, Neugebauer S, Freißmuth M, Höppener S, Figge MT, Morrison H, Riecken LB, Press AT#

Heliyon

2023-09-22

Hydrophilic cryogels as potential 3D cell culture materials: Synthesis and characterization of 2-(methacrylamido) glucopyranose-based polymer scaffolds

Behrendt F, Pretzel D, Cseresnyés Z, Kleinsteuber M, Wloka T, Radosa L, Figge MT, Gottschaldt M, Brakhage AA, Schubert US#

Journal of Polymer Science

2023-08-24

The role of pneumococcal extracellular vesicles on the pathophysiology of the kidney disease hemolytic uremic syndrome

Battista M, Hoffmann B, Bachelot Y, Zimmermann L, Teuber L, Jost A, Linde S, Westermann M, Müller MM, Slevogt H, Hammerschmidt S, Figge MT, Vilhena C*#, Zipfel PF*#

mSphere

2023-08-11

Sodium thiosulfate refuels the hepatic antioxidant pool reducing ischemia-reperfusion-induced liver injury

Press AT#*, Ungelenk L*, Medyukhina A, Pennington SA, Nietzsche S, Kan C, Lupp A, Dahmen U, Wang R, Settmacher U, Wetzker R, Figge MT, Clemens MG, Bauer M

Free Radic Biol Med

2023-05-27

Evaluation of reproducible cryogel preparation based on automated image analysis using deep learning

Behrendt F*, Cseresnyés Z*, Gerst R, Gottschaldt M, Figge MT#, Schubert US#

J Biomed Mater Res A

2023-05-09

Guided-deconvolution for correlative light and electron microscopy

Ma F, Kaufmann R, Sedzicki J, Cseresnyés Z, Dehio C, Hoeppener S, Figge MT, Heintzmann R

PLoS One

2023-04-10

Surrogate infection model predicts optimal alveolar macrophage number for clearance of Aspergillus fumigatus infections

Saffer C, Timme S, Rudolph P, Figge MT#

PJ Syst Biol Appl.

2023-03-08

Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway

Jia LJ, Rafiq M, Radosa L, Hortschansky P, Cunha C, Cseresnyés Z, Krüger T, Schmidt F, Heinekamp T, Straßburger M, Loeffler B, Doenst T, Lacerda JF, Campos A, Figge MT, Carvalho A, Kniemeyer O, Brakhage AA

Cell Host & Microbe

2023-01-31

The lipid raft-associated protein stomatin is required for accumulation of dectin-1 in the phagosomal membrane and for full activity of macrophages against Aspergillus fumigatus

Goldmann M, Schmidt F, Cseresnyés Z, Orasch T, Jahreis S, Hartung S, Figge MT, von Lilienfeld-Toal M, Heinekamp T, Brakhage AA

mSphere

2023-01-21

Tuning the corona-core ratio of polyplex micelles for selective oligonucleotide delivery to hepatocytes or hepatic immune cells

Foo WL, Cseresnyés Z, Rössel C, Teng Y, Ramoji A, Chi M, Hauswald W, Huschke S, Hoeppener S, Popp J, Schacher FH, Sierka M, Figge MT, Press AT#, Bauer M#

Biomaterials

2023-01-20

Polymer-based particles against pathogenic fungi: A non-uptake delivery of compounds

Orasch T*, Gangapurwala G*, Vollrath A, González K, Alex J, De San Luis A, Weber C, Hoeppener S, Cseresnyés Z, Figge MT, Guerrero-Sanchez C, Schubert US#, Brakhage AA#

Biomaterials Advances

2023-01-10

JIPipe: Visual batch processing for ImageJ

Gerst R*, Cseresnyés Z*, Figge MT#

Nature Methods

2023-01-01

Nasal airflow promotes default mode network activity

Salimi M, Ayene F, Parsazadegan T, Nazari M, Jamali Y, Raoufy MR

Respiratory Physiology & Neurobiology

2022-12-08

Targeting of phagolysosomes containing conidia of the human pathogenic fungus Aspergillus fumigatus with polymeric particles

González K*, Gangapurwala G*, Alex J*, Vollrath A, Cseresnyés Z, Weber C, Czaplewska JA, Hoeppener S, Svensson CM, Orasch T, Heinekamp T, Guerrero-Sánchez C, Figge MT, Schubert US, Brakhage AA

Applied Microbial and Cell Physiology

2022-10-19

Analysis of HDACi-coupled Nanoparticles: Opportunities and challenges

Kühne M, Hofmann S, Lindemann H, Cseresnyés Z, Dzierza A, Schröder D, Godmann M, Koschella A, Eggeling C, Fischer D, Figge MT, Heinze T, Heinzel T

Methods in Molecular Biology

2022-09-01

Acceptance of Different Self-sampling Methods for Semiweekly SARS-CoV-2 Testing in Asymptomatic Children and Childcare Workers at German Day Care Centers: A Nonrandomized Controlled Trial

Geraldine Engels, Johannes Forster, Andrea Streng, Viktoria Rücker, Paul Rudolph, Franziska Pietsch, Julia Wallstabe, Lars Wallstabe, Maike Krauthausen, Julia Schmidt, Timo Ludwig, Carsten Bauer, David Gierszewski , Jesper Bendig, Sandra Timme, Thomas Jans, Benedikt Weißbrich, Marcel Romanos, Lars Dölken, Peter Heuschmann, Christoph Härtel, Ildikó Gágyor, Marc Thilo Figge, Johannes Liese , Oliver Kurzai

JAMA Netw Open

2022-08-05

Toxin-producing endosymbionts shield pathogenic fungus against micropredators

Richter I, Radosa S, Cseresnyés Z, Ferling I, Büttner H, Niehs SP, Gerst R, Scherlach K, Figge MT, Hillmann F, Hertweck C

mBio

2022-08-01

Human macrophage polarization determines bacterial persistence of Staphylococcus aureus in a liver-on-chip-based infection model

Fatina Siwczak, Zoltan Cseresnyes, Mohamed I.Abdelwahab Hassan, Kehinde Oluwasegun Aina, Swen Carlstedt, Anke Sigmund, Marko Groger, Bas G.J. Surewaard, Oliver Werz, Marc Thilo Figge, Lorena Tuchscherr, Bettina Loffler, Alexander S. Mosig#

Biomaterials

2022-06-22

Spatial quantification of clinical biomarker pharmacokinetics through deep learning-based segmentation and signal-oriented analysis of MSOT data

Hoffmann B*, Gerst R*, Cseresnyés Z, Foo W, Sommerfeld O, Press AT, Bauer M, Figge MT

Photoacoustics

2022-06-10

Research data management for bioimaging: The 2021 NFDI4BIOIMAGE community survey.

Schmidt C*, Hanne J*, Moore J, Meesters C, Ferrando-May E, Weidtkamp-Peters S, members of the NFDI4BIOIMAGE initiative (incl. Svensson CM, Figge MT)

F1000Research

2022-05-10

Automated characterisation of neutrophil activation phenotypes in ex vivo human Candida blood infection

Ivan Belyaev, Alessandra Marolda, Jan-Philipp Praetorius, Arjun Sarkar, Anna Medyukhina, Kerstin Hünniger, Oliver Kurzai#, Marc Thilo Figge#

Computational and Structural Biotechnology Journal

2022-04-01

Invasive aspergillosis-on-chip: A quantitative treatment study of human Aspergillus fumigatus infection

T N M Hoang, Z Cseresnyés, S Hartung, M Blickensdorf, C Saffer, K Rennert, A S Mosig, M von Lilienfeld-Toal #, M T Figge#

Biomaterials

2022-01-01

Feasibility of SARS-CoV-2 Surveillance Testing Among Children and Childcare Workers at German Day Care Centers: A Nonrandomized Controlled Trial

Johannes Forster, Andrea Streng, Paul Rudolph , Viktoria Rücker , Julia Wallstabe , Sandra Timme , Franziska Pietsch, Katrin Hartmann, Maike Krauthausen, Julia Schmidt, Timo Ludwig, David Gierszewski, Thomas Jans, Geraldine Engels, Benedikt Weißbrich, Marcel Romanos, Lars Dölken, Peter Heuschmann , Christoph Härtel, Ildikó Gágyor, Marc Thilo Figge, Oliver Kurzai, Johannes Liese

JAMA Netw Open

2021-09-09

Bacterial endosymbionts protect beneficial soil fungus from nematode attack

Hannah Büttner*, Sarah P Niehs*, Koen Vandelannoote, Zoltán Cseresnyés, Benjamin Dose, Ingrid Richter, Ruman Gerst, Marc Thilo Figge, Timothy P Stinear , Sacha J Pidot, Christian Hertweck#

PNAS

2021-09-02

Targeted delivery of a phosphoinositide 3‐kinase γ inhibitor to restore organ function in sepsis

Adrian T Press*, Petra Babic, Bianca Hoffmann, Tina Müller, Wanling Foo, Walter Hauswald, Jovana Benecke, Martina Beretta, Zoltán Cseresnyés, Stephanie Hoeppener, Ivo Nischang, Sina M Coldewey, Markus H Gräler, Reinhard Bauer, Falk Gonnert, Nikolaus Gaßler, Reinhard Wetzker, Marc Thilo Figge, Ulrich S Schubert, Michael Bauer#

EMBO Mol Med

2021-07-16

Stealth Effect of Short Polyoxazolines in Graft Copolymers: Minor Changes of Backbone End Group Determine Liver Cell-Type Specificity

Irina Muljajew*, Sophie Huschke*, Anuradha Ramoji, Zoltán Cseresnyés, Stephanie Hoeppener, Ivo Nischang, Wanling Foo, Jürgen Popp, Marc Thilo Figge, Christine Weber, Michael Bauer, Ulrich S Schubert#, Adrian T Press#

ACS Nano

2021-06-08

Ex vivo immune profiling in patient blood enables quantification of innate immune effector functions

Teresa Lehnert*, Ines Leonhardt*, Sandra Timme, Daniel Thomas-Rüddel, Frank Bloos, Christoph Sponholz, Oliver Kurzai, Marc Thilo Figge#, Kerstin Hünniger#

Scientific Reports

2021-06-01

Enhanced segmentation of label-free cells for automated migration and interaction tracking

Ivan Belyaev, Jan-Philipp Praetorius, Anna Medyukhina, Marc Thilo Figge#

Cytometry A

2021-05-11

Mit Tropfenmikrofluidik zu Hochgeschwindigkeits-Biotechnologie

Bianka Kästner, Sundar Hengoju, Carl-Magnus Svensson, Marc Thilo Figge, Miriam A. Rosenbaum#

BIOspektrum

2021-04-03

Expression Patterns in Reductive Iron Assimilation and Functional Consequences during Phagocytosis of Lichtheimia corymbifera, an Emerging Cause of Mucormycosis

Felicia Adelina Stanford, Nina Matthies, Zoltán Cseresnyés, Marc Thilo Figge, Mohamed I Abdelwahab Hassan, Kerstin Voigt

Journal of Fungi

2021-04-01

Comparative assessment of immune evasion mechanisms in human whole-blood infection assays by a systems biology approach

Teresa Lehnert*, Maria T E Prauße, Kerstin Hünniger, Jan-Philipp Praetorius, Oliver Kurzai, Marc Thilo Figge#

PLoS One

2021-02-04

Ground truthiEtAlng from multi-rater labeling with three-way decision and possibility theory

Andrea Campagner*#, Davide Ciucci, Carl-Magnus Svensson, Marc Thilo Figge, Federico Cabitza

Information Sciences

2021-01-10

Biocompatible sulfated valproic acid-coupled polysaccharide-based nanocarriers with HDAC inhibitory activity

Marie Kühne, Henry Lindemann, Christian Grune, Daniel Schröder, Zoltán Cseresnyés, Maren Godmann, Andreas Koschella, Marc Thilo Figge, Christian Eggeling, Dagmar Fischer, Thomas Heinze#, Thorsten Heinzel#

Journal of Controlled Release

2021-01-06

Targeting Complement C5a Receptor 1 for the Treatment of Immunosuppression in Sepsis

Oliver Sommerfeld*, Anna Medyukhina, Sophie Neugebauer, Mohamed Ghait, Svenja Ulferts, Amelie Lupp, Rainer König, Reinhard Wetzker, Stefan Schulz, Marc Thilo Figge, Michael Bauer, Adrian T Press #

Molecular Therapy

2020-09-02

Quantification of Factor H Mediated Self vs. Non-self Discrimination by Mathematical Modeling

Alexander Tille, Teresa Lehnert, Peter F Zipfel, Marc Thilo Figge

Frontiers in Immunology

2020-08-18

Flotillin-Dependent Membrane Microdomains Are Required for Functional Phagolysosomes against Fungal Infections

Franziska Schmidt*, Andreas Thywißen, Marie Goldmann, Cristina Cunha, Zoltán Cseresnyés, Hella Schmidt, Muhammad Rafiq, Silvia Galiani, Markus H Gräler, Georgios Chamilos, João F Lacerda, António Campos Jr, Christian Eggeling, Marc Thilo Figge, Thorsten Heinekamp, Scott G Filler, Agostinho Carvalho, Axel A Brakhage#

Cell Reports

2020-08-12

Hybrid Agent-Based Modeling of Aspergillus fumigatus Infection to Quantitatively Investigate the Role of Pores of Kohn in Human Alveoli

Marco Blickensdorf, Sandra Timme, Marc Thilo Figge

Frontiers Microbiology

2020-06-24

Functional surface proteomic profiling reveals the host heat-shock protein A8 as a mediator of Lichtheimia corymbifera recognition by murine alveolar macrophages

Mohamed I Abdelwahab Hassan*, Janis M Kruse, Thomas Krüger, Hans-Martin Dahse, Zoltán Cseresnyés, Matthew G Blango, Hortense Slevogt, Franziska Hörhold, Volker Ast, Rainer König, Marc Thilo Figge, Olaf Kniemeyer, Axel A Brakhage, Kerstin Voigt#

Environmental Microbiology

2020-06-05

Quantitative Impact of Cell Membrane Fluorescence Labeling on Phagocytosis Measurements in Confrontation Assays

Zoltan Cseresnyes*, Mohamed I Abdelwahab Hassan*, Hans-Martin Dahse, Kerstin Voigt, Marc Thilo Figge

Frontiers in Microbiology

2020-04-30

The Transcription Factor Stp2 Is Important for Candida albicans Biofilm Establishment and Sustainability

Bettina Böttcher, Bianca Hoffmann, Enrico Garbe, Tobias Weise, Zoltán Cseresnyés, Philipp Brandt, Stefanie Dietrich, Dominik Driesch, Marc Thilo Figge, Slavena Vylkova

Frontiers in Microbiology

2020-04-16

Staphylococcus aureus Lung Infection Results in Down-Regulation of Surfactant Protein-A Mainly Caused by Pro-Inflammatory Macrophages

Elisabeth Schicke, Zoltán Cseresnyés, Knut Rennert, Vanessa Vau, Karoline Frieda Haupt, Franziska Hornung, Sandor Nietzsche, Fatina Swiczak, Michaela Schmidtke, Brigitte Glück, Mirijam Koch, Michael Schacke, Regine Heller, Alexander S Mosig, Marc Thilo Figge, Christina Ehrhardt, Bettina Löffler, Stefanie Deinhardt-Emmer

Microorganisms

2020-04-14

Human Neutrophils Produce Antifungal Extracellular Vesicles against Aspergillus fumigatus

Iordana A Shopova, Ivan Belyaev, Prasad Dasari, Susanne Jahreis, Maria C Stroe, Zoltán Cseresnyés, Ann-Kathrin Zimmermann, Anna Medyukhina, Carl-Magnus Svensson, Thomas Krüger, Viktòria Szeifert, Sandor Nietzsche, Theresia Conrad, Matthew G Blango, Olaf Kniemeyer, Marie von Lilienfeld-Toal, Peter F Zipfel, Erzsébet Ligeti, Marc Thilo Figge, Axel A Brakhage

mBio

2020-04-08

Dynamic spherical harmonics approach for shape classification of migrating cells

Anna Medyukhina*, Marco Blickensdorf*, Zoltán Cseresnyés, Nora Ruef, Jens V Stein, Marc Thilo Figge#

Scientific Reports

2020-03-31

Dynamic Interplay of Host and Pathogens in an Avian Whole-Blood Model

Sravya Sreekantapuram*, Teresa Lehnert*, Maria T E Prauße, Angela Berndt, Christian Berens, Marc Thilo Figge#, Ilse D Jacobsen#

Front Immunol

2020-03-18

Advances in Quantitative Bioimage Analysis for Proteins and Cells

Marc Thilo Figge

Cytometry A

2020-02-19

Co-infection with Staphylococcus aureus after primary influenza virus infection leads to damage of the endothelium in a human alveolus-on-a-chip model

Stefanie Deinhardt-Emmer, Knut Rennert, Elisabeth Schicke, Zoltán Cseresnyés, Maximilian Windolph, Sandor Nietzsche, Regine Heller, Fatina Siwczak, Karoline Frieda Haupt, Swen Carlstedt, Michael Schacke, Marc Thilo Figge, Christina Ehrhardt, Bettina Löffler, Alexander S Mosig

Biofabricatio

2020-01-29

Candida Species-Dependent Release of IL-12 by Dendritic Cells Induces Different Levels of NK Cell Stimulation

Alessandra Marolda*, Kerstin Hünniger, Sarah Böttcher, Wolfgang Vivas, Jürgen Löffler, Marc Thilo Figge, Oliver Kurzai#

The Journal of Infectious Diseases

2020-01-19

DeconvTest: Simulation framework for quantifying errors and selecting optimal parameters of image deconvolution

Anna Medyukhina*, Marc Thilo Figge#

Journal of Biophotonics

2020-01-16

MISA++: A standardized interface for automated bioimage analysis

Ruman Gerst*, Anna Medyukhina, Marc Thilo Figge#

SoftwareX

2019-11-22

Enolase From Aspergillus fumigatus Is a Moonlighting Protein That Binds the Human Plasma Complement Proteins Factor H, FHL-1, C4BP, and Plasminogen

Prasad Dasari, Naile Koleci, Iordana A Shopova, Dirk Wartenberg, Niklas Beyersdorf, Stefanie Dietrich, Alfredo Sahagún-Ruiz, Marc Thilo Figge, Christine Skerka, Axel A Brakhage, Peter F Zipfel#

Frontiers in Immunology

2019-11-01

A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies

Michelle Maurer, Mark S Gresnigt, Antonia Last, Tony Wollny, Florian Berlinghof, Rebecca Pospich, Zoltan Cseresnyes, Anna Medyukhina, Katja Graf, Marko Gröger, Martin Raasch, Fatina Siwczak, Sandor Nietzsche, Ilse D Jacobsen, Marc Thilo Figge, Bernhard Hube, Otmar Huber, Alexander S Mosig#

Biomaterials

2019-09-06

Regulation of the Germinal Center Reaction and Somatic Hypermutation Dynamics by Homologous Recombination

Gianna Hirth*, Carl-Magnus Svensson, Katrin Böttcher, Steffen Ullrich, Marc Thilo Figge, Berit Jungnickel#

The Journal of Immunology

2019-07-22

The geographical region of origin determines the phagocytic vulnerability of Lichtheimia strains

Mohamed I Abdelwahab Hassan*, Zoltan Cseresnyes*, Naim Al-Zaben, Hans-Martin Dahse, Rafael J Vilela de Oliveira, Grit Walther, Kerstin Voigt#, Marc Thilo Figge#

Environmental Microbiology

2019-03-01

Clinical S. aureus Isolates Vary in Their Virulence to Promote Adaptation to the Host

Lorena Tuchscherr, Christine Pöllath, Anke Siegmund, Stefanie Deinhardt-Emmer, Verena Hoerr, Carl-Magnus Svensson, Marc Thilo Figge, Stefan Monecke, Bettina Löffler

Toxins

2019-03-01

Automated tracking of label-free cells with enhanced recognition of whole tracks

Naim Al-Zaben*, Anna Medyukhina*, Stefanie Dietrich, Alessandra Marolda, Kerstin Hünniger, Oliver Kurzai, Marc Thilo Figge#

Scientific reports

2019-02-28

Lack of CD45 in FLT3-ITD mice results in a myeloproliferative phenotype, cortical porosity, and ectopic bone formation

Anne Kresinsky*, Tina M. Schnöder, Ilse D. Jacobsen, Martina Rauner, Lorenz C. Hofbauer, Volker Ast, Rainer König, Bianca Hoffmann, Carl-Magnus Svensson, Marc Thilo Figge, Ingrid Hilger, Florian H. Heidel, Frank- D. Böhmer, Jörg P. Müller #

Oncogene

2019-02-05

Comparative Assessment of Aspergillosis by Virtual Infection Modeling in Murine and Human Lung

Frontiers in Immunology

Marco Blickensdorf*, Sandra Timme, Marc Thilo Figge#

2019-01-01

Künstliche Intelligenz für die biomedizinische Bildgebung

Carl-Magnus Svensson*, und Marc Thilo Figge#

GIT Labor-Fachzeitschrift

2018-12-18

Coding of Experimental Conditions in Microfluidic Droplet Assays Using Colored Beads and Machine Learning Supported Image Analysis

Carl-Magnus Svensson*, Oksana Shvydkiv, Stefanie Dietrich, Lisa Mahler, Thomas Weber, Mahipal Choudhary, Miguel Tovar, Marc Thilo Figge#, Martin Roth#

Small

2018-10-28

Morphology-Based Distinction Between Healthy and Pathological Cells Utilizing Fourier Transforms and Self-Organizing Maps

Fabian L Kriegel*, Ralf Köhler, Jannike Bayat-Sarmadi, Simon Bayerl, Anja E Hauser, Raluca Niesner, Andreas Luch, Zoltan Cseresnyes#

Journal of Visualized Experiments

2018-08-03

Aspf2 From Aspergillus fumigatus Recruits Human Immune Regulators for Immune Evasion and Cell Damage

Prasad Dasari, Iordana A Shopova, Maria Stroe, Dirk Wartenberg, Hans Martin-Dahse, Niklas Beyersdorf, Peter Hortschansky, Stefanie Dietrich, Zoltán Cseresnyés, Marc Thilo Figge, Martin Westermann, Christine Skerka, Axel A Brakhage, Peter F Zipfel

Frontiers in Immunology

2018-07-30

Gramibactin is a bacterial siderophore with a diazeniumdiolate ligand system

Ron Hermenau, Keishi Ishida, Sofia Gama, Bianca Hoffmann, Michel Pfeifer-Leeg, Winfried Plass, Jan Frieder Mohr, Thomas Wichard, Hans-Peter Saluz, Christian Hertweck

Nature Chemical Biology

2018-06-25

Modeling Hemolytic-Uremic Syndrome: In-Depth Characterization of Distinct Murine Models Reflecting Different Features of Human Disease

Sophie Dennhardt, Wiebke Pirschel, Bianka Wissuwa, Christoph Daniel, Florian Gunzer, Sandro Lindig, Anna Medyukhina, Michael Kiehntopf, Wolfram W Rudolph, Peter F Zipfel, Matthias Gunzer, Marc Thilo Figge, Kerstin Amann, Sina M Coldewey

Frontiers in Immunology

2018-06-15

Candida albicans-Induced Epithelial Damage Mediates Translocation through Intestinal Barriers

Stefanie Allert*, Toni M Förster*, Carl-Magnus Svensson, Jonathan P Richardson, Tony Pawlik, Betty Hebecker, Sven Rudolphi, Marc Juraschitz, Martin Schaller, Mariana Blagojevic, Joachim Morschhäuser, Marc Thilo Figge, Ilse D Jacobsen, Julian R Naglik, Lydia Kasper, Selene Mogavero, Bernhard Hube

mBio

2018-06-13

Molecular signatures of liver dysfunction are distinct in fungal and bacterial infections in mice

Barbara Schaarschmidt, Sebastian Vlaic, Anna Medyukhina, Sophie Neugebauer, Sandor Nietzsche, Falk A Gonnert, Jürgen Rödel, Mervyn Singer, Michael Kiehntopf, Marc Thilo Figge, Ilse D Jacobsen, Michael Bauer#, Adrian T Press#

Theranostics

2018-04-04

Quantitative Simulations Predict Treatment Strategies Against Fungal Infections in Virtual Neutropenic Patients

Sandra Timme, Teresa Lehnert, Maria T E Prauße, Kerstin Hünniger, Ines Leonhardt, Oliver Kurzai, Marc Thilo Figge#

Frontiers of Immunology

2018-04-01

Waffenübergabe im Immunsystem

Jan Dudeck*, Anna Medyukhina*, Marc Thilo Figge#, Anne Dudeck#

Laborjournal

2018-03-26

Quantitative bioimage analysis of cell characteristics

Marc Thilo Figge

Cytometry A

2018-03-21

Predictive Virtual Infection Modeling of Fungal Immune Evasion in Human Whole Blood

Maria T E Prauße, Teresa Lehnert, Sandra Timme, Kerstin Hünniger, Ines Leonhardt, Oliver Kurzai, Marc Thilo Figge

Frontiers in Immunology

2018-01-01

Drops of blood in focus

Marc Thilo Figge

LICHTGEDANKEN

2017-11-30

Dimensionality of Motion and Binding Valency Govern Receptor–Ligand Kinetics As Revealed by Agent-Based Modeling

Teresa Lehnert*, Marc Thilo Figge#

Frontiers in Immunology

2017-10-30

Mast cells acquire MHCII from dendritic cells during skin inflammation

Jan Dudeck*, Anna Medyukhina*, Julia Fröbel, Carl-Magnus Svensson, Johanna Kotrba, Michael Gerlach, Ann-Christine Gradtke, Bernd Schröder, Stephan Speier, Marc Thilo Figge#, Anne Dudeck#

Journal of Experimental Medicine

2017-10-27

Cell shape characterization and classification with discrete Fourier transforms and self-organizing maps

Fabian L Kriegel*, Ralf Köhler, Jannike Bayat-Sarmadi, Simon Bayerl, Anja E Hauser, Raluca Niesner, Andreas Luch, Zoltan Cseresnyes#

Cytometry A

2017-10-04

Untangling cell tracks: Quantifying cell migration by time lapse image data analysis

Carl-Magnus Svensson, Anna Medyukhina, Ivan Belyaev, Naim Al-Zaben, Marc Thilo Figge#

Cytometry A

2017-09-15

Hessian-based quantitative image analysis of host-pathogen confrontation assays

Zoltan Cseresnyes, Kaswara Kraibooj, Marc Thilo Figge

Cytometry A

2017-08-26

Streptococcus pneumoniae From Patients With Hemolytic Uremic Syndrome Binds Human Plasminogen via the Surface Protein PspC and Uses Plasmin to Damage Human Endothelial Cells

Christian Meinel*, Giuseppina Spartà, Hans-Martin Dahse, Franziska Hörhold, Rainer König, Martin Westermann, Sina M Coldewey, Zoltán Cseresnyés, Marc Thilo Figge, Sven Hammerschmidt, Christine Skerka, Peter F Zipfel#

The Journal of Infectuious Diseases

2017-05-22

Automated Quantification of Early Bone Alterations and Pathological Bone Turnover in Experimental Arthritis by in vivo PET/CT Imaging

Bianca Hoffmann*, Carl-Magnus Svensson*, Maria Straßburger, Björn Gebser, Ingo M Irmler, Thomas Kamradt, Hans Peter Saluz#, Marc Thilo Figge#

Scientific Reports

2017-03-14

Quantification of arthritic bone degradation by analysis of 3D micro-computed tomography data

Carl-Magnus Svensson*, Bianca Hoffmann*, Ingo M Irmler, Maria Straßburger, Marc Thilo Figge#, Hans Peter Saluz#

Scientific Reports

2017-02-01

Fully Automated Evaluation of Total Glomerular Number and Capillary Tuft Size in Nephritic Kidneys Using Lightsheet Microscopy

Anika Klingberg, Anja Hasenberg, Isis Ludwig-Portugall, Anna Medyukhina, Linda Männ, Alexandra Brenzel, Daniel R Engel, Marc Thilo Figge, Christian Kurts, Matthias Gunzer

Journal of the American Society of Nephrology

2017-02-01

Migration and interaction tracking for quantitative analysis of phagocyte-pathogen confrontation assays

Susanne Brandes, Stefanie Dietrich, Kerstin Hünniger, Oliver Kurzai, Marc Thilo Figge#

Medical Image Analysis

2017-01-01

Systems biology of infection

Marc Thilo Figge

NOVA ACTA LEOPOLDINA

2016-08-10

Segmentation of clusters by template rotation expectation maximization

Carl-Magnus Svensson*#, Karen Grace Bondoc, Georg Pohnert, Marc Thilo Figge#

Computer Vision and Image Understanding

2016-07-02

FHR3 Blocks C3d-Mediated Coactivation of Human B Cells

Denise Buhlmann*, Hannes U Eberhardt*, Anna Medyukhina, Wolfgang M Prodinger, Marc Thilo Figge, Peter F Zipfel, Christine Skerka#

The Journal of Immunology

2016-06-01

Deciphering the Counterplay of Aspergillus fumigatus Infection and Host Inflammation by Evolutionary Games on Graphs

Johannes Pollmächer, Sandra Timme, Stefan Schuster, Axel A Brakhage, Peter F Zipfel, Marc Thilo Figge

Scientific Reports

2015-11-18

Enhanced and homogeneous oxygen availability during incubation of microfluidic droplets

Lisa Mahler, Miguel Tovar, Thomas Weber, Susanne Brandes, Martin Michael Rudolph, Josef Ehgartner, Torsten Mayr, Marc Thilo Figge, Martin Roth and Emerson Zang

RSC Advances

2015-11-01

Human neutrophils dump Candida glabrata after intracellular killing

Fabian Essig, Kerstin Hünniger, Stefanie Dietrich, Marc Thilo Figge, Oliver Kurzai

Fungal Genetics and Biology

2015-10-04

Automated Classification of Circulating Tumor Cells and the Impact of Interobsever Variability on Classifier Training and Performance

Carl-Magnus Svensson, Ron Hübler, Marc Thilo Figge

Journal of Immunology Research

2015-08-18

Identification of the antiphagocytic trypacidin gene cluster in the human-pathogenic fungus Aspergillus fumigatus

Derek J Mattern, Hanno Schoeler, Jakob Weber, Silvia Novohradská, Kaswara Kraibooj, Hans-Martin Dahse, Falk Hillmann, Vito Valiante, Marc Thilo Figge, Axel A Brakhage

Applied Microbiology and Biotechnology

2015-08-01

Image-based Systems Biology: what you get is more than you can see

Marc Thilo Figge

Laboratory Journal Europe

2015-07-15

Bottom-up modeling approach for the quantitative estimation of parameters in pathogen-host interactions

Teresa Lehnert, Sandra Timme, Johannes Pollmächer, Kerstin Hünniger, Oliver Kurzai, Marc Thilo Figge

Frontiers in Microbiology

2015-06-09

Automated quantification of the phagocytosis of Aspergillus fumigatus conidia by a novel image analysis algorithm

Kaswara Kraibooj, Hanno Schoeler, Carl-Magnus Svensson, Axel A Brakhage, Marc Thilo Figge

Frontiers in Microbiology

2015-05-28

Deciphering chemokine properties by a hybrid agent-based model of Aspergillus fumigatus infection in human alveoli

Johannes Pollmächer, Marc Thilo Figge

Frontiers in Microbiology

2015-05-28

Image-based systems biology

Marc Thilo Figge, Robert F Murphy

Cytometry A

2015-04-07

Neutrophil activation by Candida glabrata but not Candida albicans promotes fungal uptake by monocytes

Seána Duggan, Fabian Essig, Kerstin Hünniger, Zeinab Mokhtari, Laura Bauer, Teresa Lehnert, Susanne Brandes, Antje Häder, Ilse D Jacobsen, Ronny Martin, Marc Thilo Figge, Oliver Kurzai

Cellular Microbiology

2015-02-04

Quantitative image analysis of cell colocalization in murine bone marrow

Zeinab Mokhtari, Franziska Mech, Sandra Zehentmeier, Anja E Hauser, Marc Thilo Figge

Cytometry A

2015-02-01

A second stimulus required for enhanced antifungal activity of human neutrophils in blood is provided by anaphylatoxin C5a

Kerstin Hünniger, Kristin Bieber, Ronny Martin, Teresa Lehnert, Marc Thilo Figge, Jürgen Löffler, Ren-Feng Guo, Niels C Riedemann, Oliver Kurzai

The Journal of Immunology

2015-02-01

Automated segmentation and tracking of non-rigid objects in time-lapse microscopy videos of polymorphonuclear neutrophils

Susanne Brandes, Zeinab Mokhtari, Fabian Essig, Kerstin Hünniger, Oliver Kurzai, Marc Thilo Figge

Medical Image Analysis

2015-01-29

Image-based systems biology of infection

Anna Medyukhina, Sandra Timme, Zeinab Mokhtari, Marc Thilo Figge

Cytometry A

2014-10-31

Agent-based model of human alveoli predicts chemotactic signaling by epithelial cells during early Aspergillus fumigatus infection

Johannes Pollmächer, Marc Thilo Figge

PLOS One

2014-09-01

Virulent strain of Lichtheimia corymbifera shows increased phagocytosis by macrophages as revealed by automated microscopy image analysis

Kaswara Kraibooj, Hea-Reung Park, Hans-Martin Dahse, Christine Skerka, Kerstin Voigt, Marc Thilo Figge

Mycoses

2014-07-22

18 F-Fluoride positron emission tomography/computed tomography for noninvasive in vivo quantification of pathophysiological bone metabolism in experimental murine arthritis

Ingo M Irmler, Peter Gebhardt, Bianca Hoffmann, Thomas Opfermann, Marc-Thilo Figge, Hans P Saluz, Thomas Kamradt

Arthritis Research & Therapy

2014-07-15

A virtual infection model quantifies innate effector mechanisms and Candida albicans immune escape in human blood

Kerstin Hünniger, Teresa Lehnert , Kristin Bieber, Ronny Martin, Marc Thilo Figge, Oliver Kurzai

PLOS Comput Biol

2014-04-14

Automated detection of circulating tumor cells with naive Bayesian classifiers

Carl-Magnus Svensson, Solveigh Krusekopf, Jörg Lücke, Marc Thilo Figge

Cytometry A

2014-02-20

A Virtual Infection Model Quantifies Innate Effector Mechanisms and Candida albicans Immune Escape in Human Blood

Kerstin Hünniger, Teresa Lehnert , Kristin Bieber, Ronny Martin, Marc Thilo Figge, Oliver Kurzai

PLOS Computational Biology

2013-12-06

Automated characterization and parameter-free classification of cell tracks based on local migration behavior

Zeinab Mokhtari, Franziska Mech, Carolin Zitzmann, Mike Hasenberg, Matthias Gunzer, Marc Thilo Figge

PlOS One

2013-11-20

Epithelial invasion outcompetes hypha development during Candida albicans infection as revealed by an image-based systems biology approach

Franziska Mech, Duncan Wilson, Teresa Lehnert, Bernhard Hube, Marc Thilo Figge

Cytometry A

2013-06-26

Real-time image processing for label-free enrichment of Actinobacteria cultivated in picolitre droplet

Emerson Zang, Susanne Brandes, Miguel Tovar, Karin Martin, Franziska Mech, Peter Horbert, Thomas Henkel, Marc Thilo Figge, Martin Roth

Lab on a Chip

2013-05-16

Naive B-cell trafficking is shaped by local chemokine availability and LFA-1-independent stromal interactions

Fernanda M Coelho, Daniela Natale, Silvia F Soriano, Miroslav Hons, Jim Swoger, Jürgen Mayer, Renzo Danuser, Elke Scandella, Markus Pieczyk, Hans-Günter Zerwes, Tobias Junt, Andreas W Sailer, Burkhard Ludewig, James Sharpe, Marc Thilo Figge, Jens V Stein

Bloood

2013-02-18

Germinal center B cells govern their own fate via antibody feedback

Yang Zhang, Michael Meyer-Hermann, Laura A George, Marc Thilo Figge, Mahmood Khan, Margaret Goodall, Stephen P Young, Adam Reynolds, Francesco Falciani, Ari Waisman, Clare A Notley, Michael R Ehrenstein, Marie Kosco-Vilbois, Kai-Michael Toellner

Journal of Experimental Medicine

2013-01-29

Quality control of mitochondria during aging: is there a good and a bad side of mitochondrial dynamics?

Marc Thilo Figge, Heinz D Osiewacz, Andreas S Reichert

BioEssays

2012-09-12

Systems biology of microbial infection

Reinhard Guthke, Jörg Linde, Franziska Mech, Marc Thilo Figge

Frontiers in Microbiology

2012-06-28

Deceleration of Fusion–Fission Cycles Improves Mitochondrial Quality Control during Aging

Marc Thilo Figge, Andreas S Reichert, Michael Meyer-Hermann, Heinz D Osiewacz

PLOS Computational Biololgy

2012-04-26

Agent-based modeling approach of immune defense against spores of opportunistic human pathogenic fungi

Christian Tokarski, Sabine Hummert, Franziska Mech, Marc Thilo Figge, Sebastian Germerodt, Anja Schroeter, Stefan Schuster

Frontiers in Microbiology

2012-04-02

Systems biology of fungal infection

Fabian Horn, Thorsten Heinekamp, Olaf Kniemeyer, Johannes Pollmächer, Vito Valiante, Axel A Brakhage

Frontiers in Microbiology

2012-01-10

Image-based systems biology: A quantitative approach to elucidate the kinetics of fungal morphologies and virulence.

Franziska Mech, Marc Thilo

Lehrstuhl Bioinformatik Jena

2011-05-05

Automated Image Analysis of the Host-Pathogen Interaction between Phagocytes and Aspergillus fumigatus

Franziska Mech, Andreas Thywissen, Reinhard Guthke, Axel A Brakhage, Marc Thilo Figge

PLOS ONE

2011-01-01

Modelling Intravital Two-Photon Data of Lymphocyte Migration and Interaction In: Molina-París C, Lythe G (eds.) Mathematical Models and Immune Cell Biology pp

Marc Thilo Figge, Michael Meyer-Hermann

Springer Nature

2010-07-23

Toll-like Receptor 4 Signaling by Follicular Dendritic Cells Is Pivotal for Germinal Center Onset and Affinity Maturation

Alexandre Garin, Michael Meyer-Hermann, Mathias Contie, Marc Thilo Figge, Vanessa Buatois, Matthias Gunzer, Kai-Michael Toellner, Greg Elson, Marie H. Kosco-Vilbois

Immunity

2010-04-30

Modelling cellular aggregation induced by chemotaxis and phototaxis

Hasnaa Fatehi, Michael Meyer-Hermann, Marc Thilo Figge

Mathematical Medicine and Biology

2009-08-27

Mathematical modeling of the circadian rhythm of key neuroendocrine-immune system players in rheumatoid arthritis: a systems biology approach

Michael Meyer-Hermann, Marc Thilo Figge, Rainer H Straub

Arthritis & Rheumatology

2009-05-28

Optimization of Immunoglobulin Substitution Therapy by a Stochastic Immune Response Model

Marc Thilo Figge

PLOS ONE

2009-04-01

Germinal centres seen through the mathematical eye: B-cell models on the catwalk

Michael Meyer-Hermann, Marc Thilo Figge, Kai-Michael Toellner

Trends Immunology

2008-12-22

Deriving a germinal center lymphocyte migration model from two-photon data

Marc Thilo Figge, Alexandre Garin, Matthias Gunzer, Marie Kosco-Vilbois, Kai-Michael Toellner, Michael Meyer-Hermann

Rockefeller University Press

2008-05-07

Modeling receptor-ligand binding kinetics in immunological synapse formation

Marc Thilo Figge, Michael Meyer-Hermann

The European Physical Journal

2006-11-10

Geometrically repatterned immunological synapses uncover formation mechanisms

Marc Thilo Figge , Michael Meyer-Hermann

PLOS Computational Biology

2005-05-24

Stochastic discrete event simulation of germinal center reactions

Marc Thilo Figge

Physical Review E