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Spatiotemporal modeling quantifies cellular contributions to uptake of Aspergillus fumigatus in the human lung.
Commun Biol
Saffer C, Timme S, Ortiz SC, Bertuzzi M, Figge MT
Rapid detection of microbial antibiotic susceptibility via deep learning supported analysis of angle-resolved scattered-light images of picoliter droplet cultivations
Sensors and Actuators B: Chemical
Sarkar A*, Graf M*, Svensson CM, Munser A-S, Schröder S, Hengoju S, Rosenbaum M, Figge MT
The progressive increase in microbial resistance to antibiotics is a global health threat that requires solutions for rapid and reliable determination of antibiotic susceptibility in order to select appropriate antibiotics and dosages prior to treatment. We have established a screening platform that enables the detection of cell growth after just a few cell divisions. Our […]
Tracking the uptake of labelled host-derived extracellular vesicles by the human fungal pathogen Aspergillus fumigatus
microLife
Visser C, Rivieccio F, Krüger T, Schmidt F, Cseresnyés Z, Rohde M, Figge MT, Kniemeyer O,Blango MG*, Brakhage AA*
Extracellular vesicles (EVs) have gained attention as facilitators of intercellular as well as interkingdom communication during host-microbe interactions. Recently we showed that upon infection, host polymorphonuclear leukocytes produce antifungal EVs targeting the clinically important fungal pathogen Aspergillus fumigatus; however, the small size of EVs (< 1 µm) complicates their functional analysis. Here, we employed a more […]
Aspergillus fumigatus-derived gliotoxin impacts innate immune cell activation through modulating lipid mediator production in macrophages
Immunology
Günther K, Nischang V, Cseresnyés Z, Krüger T, Sheta D, Abboud Z, Heinekamp T, Werner M, Kniemeyer O, Beilhack A, Figge MT, Brakhage AA, Werz O#, Jordan PM#
Gliotoxin (GT), a secondary metabolite and virulence factor of the fungal pathogen Aspergillus fumigatus, suppresses innate immunity and supports the suppression of host immune responses. Recently, we revealed that GT blocks the formation of the chemotactic lipid mediator leukotriene (LT)B4 in activated human neutrophils and monocytes, and in rodents in vivo, by directly inhibiting LTA4 […]
Engineering Adhesion of the Probiotic Strain Escherichia coli Nissle to the Fungal Pathogen Candida albicans
ACS Synth Biol
Chamas A#, Svensson CM, Maneira C, Sporniak M, Figge MT, Lackner G
Engineering live biotherapeutic products against fungal pathogens such as Candida albicans has been suggested as a means to tackle the increasing threat of fungal infections and the development of resistance to classical antifungal treatments. One important challenge in the design of live therapeutics is to control their localization inside the human body. The specific binding […]
Metamizole outperforms meloxicam in sepsis: insights on analgesics, survival and immunomodulation in the peritoneal contamination and infection sepsis model
Frontiers in Immunology
Liu N, Sonawane M, Sommerfeld O, Svensson CM, Figge MT, Bauer Reinhard , Bischoff SJ,Bauer M, Osuchowski MF, Press AT
Background: Limited availability and side effects of opioids have led to an increased use of non-opioid analgesia in animal disease models. However, by affecting the immune-inflammatory reactions, analgesia may disrupt the resolution of the host inflammation and modulate the survival in septic animals. This study used a clinically relevant sepsis mouse model of peritoneal contamination […]
NFDI4BIOIMAGE – National research data infrastructure for microscopy and bioimage analysis
zenodo
Moore J#, Kunis S, Grüning B, Blank-Burian M, Mallm JP, Stöter T, Zuschratter W, Figge MT, Kreshuk A, Tischer C, Haase R, Zobel T, Bauer P, Svensson CM, Gerst R, Hanne J, Schmidt C, Becker MM, Bocklitz T, Bumberger J, Chalopin C, Chen J, Czodrowski P, Dickscheid T, Fortmann- Grote C, Huisken J, Lohmann J, Schauss A, Baumann M, Beretta C, Burel JM, Heuveline C, Kuner R, Kuner T, Landwehr M, Leibfried A, Nitschke R, Mittal D, von Suchodoletz D, Valencia- Schneider M, Zentis P, Brilhaus D, Hartley M, Hülsmann B, Dunker S, Keppler A, Mathur A, Meesters C, Möbius W, Nahnsen S, Pfander C, Rehwald S, Serrano-Solano B, Vilardell Scholten L, Vogl R, Becks L, Ferrando-May E*#, Weidtkamp-Peters S*#
Bioimaging refers to a collection of methods to visualize the internal structures and mechanisms of living organisms. The fundamental tool, the microscope, has enabled seminal discoveries like that of the cell as the smallest unit of life, and continues to expand our understanding of biological processes. Today, we can follow the interaction of single molecules […]
Unique target binding by the C-terminal Region of FHR1 provides a new perception of aHUS Pathology
FHR1 is a multifunctional human plasma protein with three C-terminal domains, namely short consensus repeats (SCR) 3-5, showing 98% sequence-identity with the complement inhibitor Factor H. We show that FHR1 uses all three C-terminal SCR to make surface contact. The conserved C-terminal regions of FHR1 and Factor H are altered in patients with atypicalhemolytic-uremic-syndrome. Therefore, […]
Competitive inhibition and mutualistic growth in Co infections: deciphering Staphylococcus aureus – Acinetobacter baumannii interaction dynamics
ISME Commun
Timme S*, Wendler S*, Klassert TE, Saraiva JP, Nunes da Rocha U, Wittchen M, Schramm S, Ehricht R, Monecke S, Edel B, Rödel J, Löffler B, Soledad Ramirez M, Slevogt H, Figge MT*#, Tuchscherr L*#
Staphylococcus aureus (Sa) and Acinetobacter baumannii (Ab) are frequently co-isolated from polymicrobial infections that are severe and refractory to therapy. Here, we apply a combination of wet-lab experiments and in silico modeling to unveil the intricate nature of the Ab/Sa interaction using both, representative laboratory strains and strains co-isolated from clinical samples.This comprehensive methodology allowed […]
Impact of functional electrical stimulation on nerve-damaged muscles by quantifying fat infiltration using deep learning
Scientific Reports
Walluks, K.*, Praetorius*, JP., Arnold, D. #, Figge, M. T.# *contributed equally and #contributed equally
Quantitative imaging in life sciences has evolved into a powerful approach combining advanced microscopy acquisition and automated analysis of image data. The focus of the present study is on the imaging-based evaluation of the posterior cricoarytenoid muscle (PCA) influenced by long-term functional electrical stimulation (FES), which may assist the inspiration of patients with bilateral vocal […]