Hyphal growth simulation

In this project, the growth of fungal hyphae is modeled. As a parameterized approach, different hyphal structures can be learned, simulated and reproduced for further analysis or applications. The algorithm is implemented as a recursive approach, which allows to potentially grow a new hyphal branch at each depth level. The angle of curvature, frequency of new branching, and piercing (in the alveolus) is also parameterized, making it highly adaptable for different scenarios. Interactions with immune cells (alveolar macrophages) is realized according to the set of rules within the agent-based modeling.

Simulation of hyphal growth in various environments

Hyphal growth in 2D

projects-hyphal-growth-simulation-2d.mp4

Hyphal growth in human alveolus

projects-hyphal-growth-simulation-albeolus.mp4

Publications

2023-04-10

Surrogate infection model predicts optimal alveolar macrophage number for clearance of Aspergillus fumigatus infections

Saffer C, Timme S, Rudolph P, Figge MT#

PJ Syst Biol Appl.

2023-01-20

Polymer-based particles against pathogenic fungi: A non-uptake delivery of compounds

Orasch T*, Gangapurwala G*, Vollrath A, González K, Alex J, De San Luis A, Weber C, Hoeppener S, Cseresnyés Z, Figge MT, Guerrero-Sanchez C, Schubert US#, Brakhage AA#

Biomaterials Advances

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