In this project, an antimicrobial peptide (AMP) evasion mechanism is modeled and simulated. This mechanism, which we refer to as spatial distancing, consists of a pathogen cell secreting defense molecules that can bind to AMP and form complexes with the highest concentration close to the cell surface that diffuse away from the pathogen. As a result, AMP are transported away from the pathogen’s surface, effectively protecting it from the immune attack by AMP.
The modeling of spatial distancing, where pathogens secrete defense molecules that bind AMPs, resulting in the pathogen evading the immune system.
