The increasing availability of complex imaging techniques requires scalable and reproducible software solutions that are capable of utilizing all information in high-resolution, multimodal image data. JIPipe is an open-source, metadata-driven image analysis platform for visually creating analysis pipelines without requiring programming expertise. The tool is designed for a wide range of applications and has already been successfully applied in studies concerning molecular and cellular level biology, drug delivery characterization, and materials sciences. This image analysis platform can also provide a versatile solution for imaging core facilities by promoting FAIR compliance when building workflows.