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Spatial quantification of clinical biomarker pharmacokinetics through deep learning-based segmentation and signal-oriented analysis of MSOT data
Photoacoustics
Hoffmann B*, Gerst R*, Cseresnyés Z, Foo W, Sommerfeld O, Press AT, Bauer M, Figge MT
Although multispectral optoacoustic tomography (MSOT) significantly evolved over the last several years, there is a lack of quantitative methods for analysing this type of image data. Current analytical methods characterise the MSOT signal in manually defined regions of interest outlining selected tissue areas. These methods demand expert knowledge of the sample anatomy, are time consuming, […]
Feasibility of SARS-CoV-2 Surveillance Testing Among Children and Childcare Workers at German Day Care Centers: A Nonrandomized Controlled Trial
Controlled Clinical Trial
Johannes Forster 1 , Andrea Streng 2 , Paul Rudolph 3 , Viktoria Rücker 4 , Julia Wallstabe 1 , Sandra Timme 3 , Franziska Pietsch, Katrin Hartmann, Maike Krauthausen, Julia Schmidt, Timo Ludwig, David Gierszewski, Thomas Jans, Geraldine Engels, Benedikt Weißbrich, Marcel Romanos, Lars Dölken, Peter Heuschmann , Christoph Härtel, Ildikó Gágyor, Marc Thilo Figge, Oliver Kurzai, Johannes Liese
Importance: Closure of day care centers has been implemented globally to contain the COVID-19 pandemic but has negative effects on children’s health and psychosocial well-being. Objective: To investigate the feasibility of surveillance among children and childcare workers and to model the efficacy of surveillance on viral spread prevention. Design, setting, and participants: This nonrandomized controlled […]
Quantitative Impact of Cell Membrane Fluorescence Labeling on Phagocytosis Measurements in Confrontation Assays
Front Microbiol.
Zoltan Cseresnyes, Mohamed I. Abdelwahab Hassan, Hans-Martin Dahse, Kerstin Voigt and Marc Thilo Figge
Phagocytosis is series of steps where the pathogens and the immune cells interact during an invasion. This starts with the adhesion process between the host and pathogen cells, and is followed by the engulfment of the pathogens. Many analytical methods that are applied to characterize phagocytosis based on imaging the host–pathogen confrontation assays rely on […]
Hessian-based quantitative image analysis of host-pathogen confrontation assays
Cytometry A
Zoltan Cseresnyes, Kaswara Kraibooj, Marc Thilo Figge
Host-fungus interactions have gained a lot of interest in the past few decades, mainly due to an increasing number of fungal infections that are often associated with a high mortality rate in the absence of effective therapies. These interactions can be studied at the genetic level or at the functional level via imaging. Here, we […]
Bottom-up modeling approach for the quantitative estimation of parameters in pathogen-host interactions
Front Microbiol
Teresa Lehnert, Sandra Timme, Johannes Pollmächer, Kerstin Hünniger, Oliver Kurzai, Marc Thilo Figge
Opportunistic fungal pathogens can cause bloodstream infection and severe sepsis upon entering the blood stream of the host. The early immune response in human blood comprises the elimination of pathogens by antimicrobial peptides and innate immune cells, such as neutrophils or monocytes. Mathematical modeling is a predictive method to examine these complex processes and to […]
A virtual infection model quantifies innate effector mechanisms and Candida albicans immune escape in human blood
PLOS Comput Biol
Kerstin Hünniger, Teresa Lehnert , Kristin Bieber, Ronny Martin, Marc Thilo Figge, Oliver Kurzai
Candida albicans bloodstream infection is increasingly frequent and can result in disseminated candidiasis associated with high mortality rates. To analyze the innate immune response against C. albicans, fungal cells were added to human whole-blood samples. After inoculation, C. albicans started to filament and predominantly associate with neutrophils, whereas only a minority of fungal cells became […]