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A virtual infection model quantifies innate effector mechanisms and Candida albicans immune escape in human blood
PLOS Comput Biol
Kerstin Hünniger, Teresa Lehnert , Kristin Bieber, Ronny Martin, Marc Thilo Figge, Oliver Kurzai
Candida albicans bloodstream infection is increasingly frequent and can result in disseminated candidiasis associated with high mortality rates. To analyze the innate immune response against C. albicans, fungal cells were added to human whole-blood samples. After inoculation, C. albicans started to filament and predominantly associate with neutrophils, whereas only a minority of fungal cells became […]