Download Publication Data
If you are looking for files associated to our publications, please click the following link. You will be forwarded to our publication data site.
All publications
Bottom-up modeling approach for the quantitative estimation of parameters in pathogen-host interactions
Front Microbiol
Teresa Lehnert, Sandra Timme, Johannes Pollmächer, Kerstin Hünniger, Oliver Kurzai, Marc Thilo Figge
Opportunistic fungal pathogens can cause bloodstream infection and severe sepsis upon entering the blood stream of the host. The early immune response in human blood comprises the elimination of pathogens by antimicrobial peptides and innate immune cells, such as neutrophils or monocytes. Mathematical modeling is a predictive method to examine these complex processes and to […]
A virtual infection model quantifies innate effector mechanisms and Candida albicans immune escape in human blood
PLOS Comput Biol
Kerstin Hünniger, Teresa Lehnert , Kristin Bieber, Ronny Martin, Marc Thilo Figge, Oliver Kurzai
Candida albicans bloodstream infection is increasingly frequent and can result in disseminated candidiasis associated with high mortality rates. To analyze the innate immune response against C. albicans, fungal cells were added to human whole-blood samples. After inoculation, C. albicans started to filament and predominantly associate with neutrophils, whereas only a minority of fungal cells became […]