In this project, the growth of fungal hyphae is modeled. As a parameterized approach, different hyphal structures can be learned, simulated and reproduced for further analysis or applications. The algorithm is implemented as a recursive approach, which allows to potentially grow a new hyphal branch at each depth level. The angle of curvature, frequency of new branching, and piercing (in the alveolus) is also parameterized, making it highly adaptable for different scenarios. Interactions with immune cells (alveolar macrophages) is realized according to the set of rules within the agent-based modeling.
Hyphal growth simulation
Publications
pyPESTO: a modular and scalable tool for parameter estimation for dynamic models.
Schälte Y*, Fröhlich F*, Jost PJ*, Vanhoefer J*, Pathirana D, Stapor P, Lakrisenko P, Wang D, Raimúndez E, Merkt S, Schmiester L, Städter P, Grein S, Dudkin E, Doresic D, Weindl D, Hasenauer J#
Summary: Mechanistic models are important tools to describe and understand biological processes. However, they typically rely on unknown parameters, the estimation of which can be challenging for large and complex systems. pyPESTO is a modular framework for systematic parameter estimation, with scalable algorithms for optimization and uncertainty quantification. While tailored to ordinary differential equation problems, […]
Quantitative analysis of peroxisome tracks using a Hidden Markov Model.
Svensson CM*, Reglinski K*, Schliebs W, Erdmann R, Eggeling C#, Figge MT#
Diffusion and mobility are essential for cellular functions, as molecules are usually distributed throughout the cell and have to meet to interact and perform their function. This also involves the cytosolic migration of cellular organelles. However, observing such diffusion and interaction dynamics is challenging due to the high spatial and temporal resolution required and the […]
Contribution of Radixin and Ezrin to the maintenance of hepatocytes’ excretory function in health and disease.
Dellbrügge F, Jesse LD, Medyukhina A, Liu N, Neugebauer S, Freißmuth M, Höppener S, Figge MT, Morrison H, Riecken LB, Press AT#
Background & aimsExcretory liver failure is frequently associated with poor prognosis in critically ill patients. It is characterized by the loss of canalicular membrane export pumps at the hepatocyte membrane. The membrane export pump Multidrug resistant-associated protein (MRP) 2 is pivotal in hepatocytes for brushed membrane morphology and transport of various metabolites. In addition, MRP2 […]