A. fumigatus infection in virtual alveolus

In this project, a virtual infection with A. fumigatus in human or murine alveolus is simulated. The corresponding model considers a realistic to-scale representation of the alveolus, consisting of a 3⁄4 sphere, with alveolar epithelial cells (AEC) of type 1 and 2 as well as pores of Kohn (PoK). Moreover, the AEC, on which a conidium is located, secretes chemokines that diffuse on the inner surface of the alveolus using a system of partial differential equations (PDE). Alveolar macrophages (AM), that represent the first line of immune cells, are able to sense the chemokine gradient using an intracellular receptor-ligand model based on ordinary differential equations (ODE), which directs their migration towards the conidium. The use of this hybrid spatio-temporal approach to modeling interactions between agents at the cellular level allowed us to perform a large number of simulations to gain a quantitative understanding, address open questions, and contribute to the scientific field.

Realistic to-scale representation of murine (left) and human (right) alveolus, consisting of a 3⁄4 sphere and its components.

Virtual infection scenario with A. fumigatus:

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